Rabbit Secondary Antibodies
ABclonal Technology ABflo 488 Rabbit anti-Dog CD19
This gene encodes a cell surface protein from the immunoglobulin gene superfamily expressed mainly in B cell lymphocytes It serves as a marker for pre-B cells but is downregulated in antibody-secreting plasma cells The protein features two extracellular Ig-like domains a non-Ig-like domain a hydrophobic transmembrane region and a large C-terminal cytoplasmic domain It forms a complex with CD21 and CD81 reducing the activation threshold for B cells Activation of this complex triggers the phosphatidylinositol 3-kinase pathway and calcium ion release This protein is targeted by CAR T-cells in lymphoblastic leukemia treatment Mutations are linked to common variable immunodeficiency 3 (CVID3) causing B-cell differentiation failure hypogammaglobulinemia and recurrent infections Alternative splicing produces multiple isoforms
Cell Signaling Technology PSAKLK3 D2A8 Rabbit mAb BSA and Azide Free 100 ug
PSAKLK3 D2A8 Rabbit mAb BSA and Azide Free 100 ug
ABclonal Technology PCSK9 Rabbit mAb
This gene encodes a member of the subtilisin-like proprotein convertase family which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network It is expressed in liver intestine and kidney tissues and escorts specific receptors for lysosomal degradation It plays a role in cholesterol and fatty acid metabolism Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia Alternative splicing results in multiple transcript variants
ABclonal Technology 647 Rabbit anti- IL1R1/CD121a
Enables interleukin-1 binding activity interleukin-1 receptor activity and protease binding activity Involved in interleukin-1-mediated signaling pathway Acts upstream of or within several processes including cytokine-mediated signaling pathway positive regulation of interleukin-1-mediated signaling pathway and positive regulation of neutrophil extravasation Located in external side of plasma membrane Is expressed in brain dorsal aorta liver reproductive system and spleen Used to study type 1 diabetes mellitus Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus Orthologous to human IL1R1 (interleukin 1 receptor type 1)
ABclonal Technology APC Rabbit anti-Mouse CD93 mAb
Predicted to enable complement component C1q complex binding activity Predicted to be involved in cell-cell adhesion Predicted to act upstream of or within cell adhesion Located in cell surface cytoplasmic vesicle and plasma membrane Is expressed in blood vessel Orthologous to human CD93 (CD93 molecule)
ABclonal Technology Cip4 Rabbit mAb
Enables identical protein binding activity Predicted to be involved in actin cytoskeleton organization endocytosis and signal transduction Located in nucleoplasm Biomarker of Huntington s disease
ABclonal Technology GATA1 Rabbit mAb
This gene encodes a protein which belongs to the GATA family of transcription factors The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia
ABclonal Technology CD93 Rabbit mAb
Predicted to enable complement component C1q complex binding activity Predicted to be involved in cell-cell adhesion Predicted to act upstream of or within cell adhesion Located in cell surface cytoplasmic vesicle and plasma membrane Is expressed in blood vessel Orthologous to human CD93 (CD93 molecule)