Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 610 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation Mutations in this gene are associated with lung cancer
ABclonal Technology 488 Rabbit anti-/Human CD55
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis This gene is located adjacent to a closely related gene on chromosome 1
ABclonal Technology 647 Rabbit anti-Human CD93
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker The encoded protein was once thought to be a receptor for C1q but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells The intracellular cytoplasmic tail of this protein has been found to interact with moesin a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton
ABclonal Technology 700 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology 488 Rabbit anti-Human SIGLEC9
Predicted to enable monosaccharide binding activity and sialic acid binding activity Predicted to be involved in cell adhesion Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis engulfment Predicted to be located in external side of plasma membrane Predicted to be active in plasma membrane
Jackson Immuno Research Labs Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
Fluorescein (FITC)-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
ABclonal Technology 647 Rabbit anti-Human CD84
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells Alternate splicing results in multiple transcript variants
ABclonal Technology PE Rabbit anti-Human/ FOXP3
The protein encoded by this gene is a member of the forkhead winged-helix family of transcriptional regulators Defects in this gene are the cause of immunodeficiency polyendocrinopathy enteropathy X-linked syndrome (IPEX) also known as X-linked autoimmunity-immunodeficiency syndrome Alternatively spliced transcript variants encoding different isoforms have been identified
ABclonal Technology 488 Rabbit anti-Human NG2
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells
ABclonal Technology 647 Rabbit anti-Human GSK3B
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is a negative regulator of glucose homeostasis and is involved in energy metabolism inflammation ER-stress mitochondrial dysfunction and apoptotic pathways Defects in this gene have been associated with Parkinson disease and Alzheimer disease
ABclonal Technology 594 Rabbit anti-Human NG2
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells
ABclonal Technology 647 Rabbit anti-Human CD47
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD9 mAb
This gene encodes a member of the transmembrane 4 superfamily also known as the tetraspanin family Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins The encoded protein functions in many cellular processes including differentiation adhesion and signal transduction and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis